135879-69-5

Upstream product

• 15754-20-8 (E)-acetophenone O-methyloxime 
• 3376-33-8 O-methyl acetophenone oxime 
• 2912-98-3 (R)-1-Phenylethylhydroxylamine 
• 395663-80-6 C₁₁H₁₉NOSi 
• 395663-84-0 (R)-N-hydroxy-N-(α-methylbenzyl)propanamide 
• 395663-85-1 (R)-N-methoxy-N-(α-methylbenzyl)propanamide 

Relevant academic research and scientific papers

Synthesis of (R)-{η6-[O-methyl-N-(α-methylbenzyl)hydroxyamino]benzene} chromium tricarbonyl via nucleophilic aromatic substitution of (η6-fluorobenzene) chromium tricarbonyl

Chiral hydroxylamine chromium tricarbonyl complexes may be prepared in satisfactory to reasonable yield via nucleophilic aromatic substitution of the anion derived from N,O-substituted hydroxylamines and (η6-fluorobenzene) chromium tricarbonyl. The enantiomerically pure complex (R)-{η6-[O-methyl-N-(α-methylbenzyl)hydroxyamino]benzene} chromium tricarbonyl 6a was characterised by X-ray crystallography.

Enantiomerically pure 2-piperazinemethanols as novel chiral ligands of oxazaborolidine catalysts in enantioselective borane reductions

Novel enantiomerically pure 2-piperazinemethanols (3-5) were synthesized from 2-piperazinecarboxylic acid 1. The asymmetric reduction of aromatic ketones, ketimine and oxime ether has been performed with reagents prepared from 2-piprazinemethanol and borane to yield enantiomerically enriched alcohols and amines, respectively. The preferred absolute configuration of the product was dependent on the structure of the sulfonyl substituent in the chiral ligand.

Chemo-enzymatic synthesis of 1,2- and 1,3- amino-alcohols and their use in the enantioselective reduction of acetophenone and anti-acetophenone oxime methyl ether with borane

New chiral amino-alcohols were enantioselectively synthesized using biotransformations as the key steps. They were used as ligand in the enantioselective borane reduction of acetophenone and of the corresponding anti oxime methyl ether.