135883-31-7Relevant academic research and scientific papers
METHODS FOR TREATING RETINOID RESPONSIVE DISORDERS USING SELECTIVE INHIBITORS OF CYP26A AND CYP26B
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Page/Page column 171, (2008/06/13)
The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.
Alkyl, alkoxy and thioalkoxy substituted diphenyl acetylenes having retinoid like activity
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, (2008/06/13)
Retinoid like activity is exhibited by compounds of the formula STR1 where R1 -R4 independently are hydrogen, lower alkyl, cycloalkyl or lower alkenyl, A and B independently are hydrogen, lower alkyl cycloalkyl, lower alkenyl, SR* or
Acetylenes disubstituted with a pyridinyl group and a substituted phenyl group having retinoid like activity
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, (2008/06/13)
Retinold like activity is exhibited by compounds of the formula STR1 where R1 -R3 independently are hydrogen, lower alkyl, cycloalkyl or lower alkenyl, A and B independently are hydrogen, lower alkyl, cycloalkyl, lower alkenyl, SRsu
