135885-95-9Relevant academic research and scientific papers
Access to 2-Amino-3-Arylthiophenes by Base-Catalyzed Redox Condensation Reaction Between Arylacetonitriles, Chalcones, and Elemental Sulfur
Nguyen, Thi Thu Tram,Le, Van Anh,Retailleau, Pascal,Nguyen, Thanh Binh
supporting information, p. 160 - 165 (2019/12/11)
A straightforward access to 2-amino-3-arylthiophenes has been developed via one-pot two-step three-component reaction of arylacetonitriles, chalcones and elemental sulfur. The first step consists of a DBU-catalyzed formation of Michael adduct between aryl
New aspects of Michael reaction: Reaction of 1,3-diarylpropenones with active cyano compounds
El-Sadany, S K,Sharaf, S M,Darwish, A I,Youssef, A A
, p. 567 - 573 (2007/10/02)
Ethyl 2-cyano-5-oxo-3,5-diarylpentanoates (7a-k) and 1,3,5-triaryl-2-aroyl-4-cyano-4-carboethoxycyclohexanols (6a-e,g,i,k) are obtained when the corresponding 1,3-diarylpropenones (1a-k) are reacted with ethyl cyanoacetate in the presence of different ratios of ethoxide ion.The cyclic products (6) are also obtained by treating the corresponding mono-condensation products (7) with sodium ethoxide.Furthermore, 3-aryl-4-benzoyl-2-phenylbutyronitriles (8) are obtained from the reaction of 1 with benzylcyanide in equimolar amounts in the presence of sodium ethoxide. 2-Benzoyl-4-cyano-1,3,4,5-tetraphenylcyclohexanol (9) is however, obtained when two moles of 1a are treated with one mole of benzylcyanide in the presence of ethoxide ion.The mono-condensation product 8 when treated with sodium ethoxide does not give 9.The cyclohexanol compound 11a is also obtained by the reaction of 1a with malononitrile.The structures of all the compounds have been established by elemental analysis and spectral data (IR, UV, 1H NMR and 13C NMR).
