135903-77-4Relevant academic research and scientific papers
A flexible synthesis of privileged structural motifs using the Ollis-Sweeney ammonium ylid rearrangement
Gasiecki, Alan F.,Cross, Jeffrey L.,Henry, Rodger F.,Gracias, Vijaya,Djuric, Stevan W.
scheme or table, p. 6286 - 6288 (2009/04/06)
The Ollis-Sweeney ammonium ylid rearrangement has been effectively utilized to provide access to hitherto unknown hybrid privileged structural motifs. The rearrangement of didehydropiperidinium salts containing tethered olefins at the 4-position afforded, after subsequent ring closing metathesis, novel spirocyclic scaffolds suitable for further elaboration and incorporation of final structures into HTS sets.
(N-phthalimidoalkyl) piperidines useful as treatments for psychosis
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, (2008/06/13)
There is described novel (N-phthalimidoalkyl) piperidine compounds which exhibit selective sigma-receptor antagonism and therefore are useful in the treatment of physiological or drug induced psychosis and dyskinesia in a mammal. Also described are pharmaceutical compositions containing sigma selective compounds and methods of using these compositions for treating physiological or drug induced psychosis or dyskinesia in a mammal. Further provided are methods for preparing the compounds of this invention.
