135907-99-2

Basic information

• Product Name: (2-hydroxy-3-tosyl)propyl thiocyanate
• Synonyms: (2-hydroxy-3-tosyl)propyl thiocyanate
• CAS NO: 135907-99-2
• Molecular Weight: 271.361
• Mol File: 135907-99-2.mol

Chemical Properties

• CAS DataBase Reference: (2-hydroxy-3-tosyl)propyl thiocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: (2-hydroxy-3-tosyl)propyl thiocyanate(135907-99-2)
• EPA Substance Registry System: (2-hydroxy-3-tosyl)propyl thiocyanate(135907-99-2)

Safety Data

• Hazardous Substances Data: 135907-99-2(Hazardous Substances Data)

Upstream product

• 106-45-6 para-thiocresol 
• 5373-01-3 p-tolylsulfanylmethyl-oxirane 
• 1147550-11-5 ammonium thiocyanate 
• 118356-16-4 2-(p-toluenesulfonylmethyl)oxirane 

Downstream Products

• 1309922-51-7 1-(p-toluenesulfonyl)-3-thiocyanatopropan-2-yl acetate 

Relevant articles and documents

Simple synthesis of β-acetoxy thiocyanates from oxiranes

A convenient and simple method for the preparation of previously unknown β-acetoxy thiocyanates by regioselective ring opening of the corresponding oxiranes with thiocyanate anion followed by acetylation is described. The shorter reaction times, better yields of the products, and easy workup are the advantages of this methodology.

β,γ-EPOXY SULFONES IN ORGANIC SYNTHESIS. PART 2: PREPARATION OF β,γ-BIFUNCIONALIZED SULFONES

Heteronucleophiles reagents react with β,γ-epoxy sulfones 1 at the γ position in the presence of Ti(OPri)4 or magnesium halides to afford regioselectively γ-functionalized β-hydroxy sulfones 2.With soft nucleophiles such as sodium azide, triphenylphosphine, or sodium benzethiolate the reaction takes place in the absence of Lewis acids.In the case of basic reagents such as sodium methoxide or diethylamine the corresponding regioisomers, the β-functionalized γ-hydroxy sulfones 3 were exclusively obtained.The preparation of compounds 3 (R2 = H) was also carried out starting from 3-tosyl-2-propen-1-ol (4) by Michael addition of different heteronucleophiles.