135912-89-9

Upstream product

• 135912-87-7 O^ω-<(2S,2R)-2-<<<(4S,5R)-4-(cyclohexylmethyl)-3-<(1,1-dimethylethoxy)carbonyl>-2,2-dimethyl-5-oxazolidinyl>carbonyl>oxy>-3-(4-morpholino)propyl>-N^α-<(phenylmethoxy)carbonyl>-L-glutamic acid, 1,1-dimethylethyl ester 
• 135912-88-8 (8S,11S,12R)-2-butyl-11-(cyclohexylmethyl)-12-hydroxy-2-(4-morpholinomethyl)-8-<<(phenylmethoxy)carbonyl>amino>-5,9,13-trioxo-1,4-dioxa-10-azacyclotridecane 
• 135912-86-6 Z-Glu<(2S,2R)-2-hydroxy-3-(4-morpholino)propyl>-OtBu 
• 135912-85-5 (S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-tert-butyl ester 5-oxiranylmethyl ester 
• 34897-61-5 N-(benzyloxycarbonyl)-L-glutamic acid α-t-butyl ester dicyclohexylamine salt 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 1054620-65-3 (6R,7S,10S)-10-Amino-7-cyclohexylmethyl-6-hydroxy-3-morpholin-4-ylmethyl-1,4-dioxa-8-aza-cyclotridecane-5,9,13-trione 

Relevant academic research and scientific papers

Highly Potent, Orally Active Diester Macrocyclic Human Renin Inhibitors

Replacing one amide bond in macrocyclic renin inhibitors of the general structure 1 and 2 with an ester linkage gave glutamate-derived inhibitors 3 and serine-derived inhibitors 4.While this oxygen-for-nitrogen exchange had little effect on potency in the