135912-85-5

Upstream product

• 556-52-5 oxiranyl-methanol 
• 34897-61-5 N-(benzyloxycarbonyl)-L-glutamic acid α-t-butyl ester dicyclohexylamine salt 

Downstream Products

• 135912-89-9 (8S,11S,12R)-11-(cyclohexylmethyl)-12-hydroxy-2-(4-morpholinomethyl)-8--L-phenylalanyl>-5,9,13-trioxo-1,4-dioxa-10-azacyclotridecane 
• 135912-88-8 (8S,11S,12R)-2-butyl-11-(cyclohexylmethyl)-12-hydroxy-2-(4-morpholinomethyl)-8-<<(phenylmethoxy)carbonyl>amino>-5,9,13-trioxo-1,4-dioxa-10-azacyclotridecane 
• 1054620-65-3 (6R,7S,10S)-10-Amino-7-cyclohexylmethyl-6-hydroxy-3-morpholin-4-ylmethyl-1,4-dioxa-8-aza-cyclotridecane-5,9,13-trione 
• 135912-86-6 Z-Glu<(2S,2R)-2-hydroxy-3-(4-morpholino)propyl>-OtBu 

Relevant academic research and scientific papers

Highly Potent, Orally Active Diester Macrocyclic Human Renin Inhibitors

Replacing one amide bond in macrocyclic renin inhibitors of the general structure 1 and 2 with an ester linkage gave glutamate-derived inhibitors 3 and serine-derived inhibitors 4.While this oxygen-for-nitrogen exchange had little effect on potency in the