1359132-58-3Relevant articles and documents
A facile one-pot, three-component synthesis of a new series of thiazolyl pyrazole carbaldehydes: In vitro anticancer evaluation, in silico ADME/T, and molecular docking studies
Mamidala, Srikanth,Aravilli, R Kowshik,Ramesh, Gondru,Khajavali, Shaik,Chedupaka, Raju,Manga, Vijjulatha,Vedula, Rajeswar Rao
, (2021)
A series of thiazolyl pyrazole carbaldehydes (4a-n) were synthesized by conventional method using thiosemicarbazide, substituted phenacyl bromides, substituted 3-acetylcoumarins, and Vilsmeyer-Hack reagent. Structures of all the synthesized compounds were confirmed by spectral (1H & 13C NMR, FTIR, Mass) and analytical data. The target compounds were screened for their in vitro anticancer activity. From the results, it was found that the compound 4m has shown significant antiproliferative activity against all tested cell-lines. Furthermore, in silico ADME/T profiles were also carried out to set effective lead candidates for the future anticancer drug discovery initiatives. Molecular docking studies were carried out against colchicine binding site of β-tubulin and the results were in concordance with the in vitro anticancer data.
A convenient ultrasound-promoted synthesis of some new thiazole derivatives bearing a coumarin nucleus and their cytotoxic activity
Gomha, Sobhi M.,Khalil, Khaled D.
, p. 9335 - 9347 (2012/11/07)
Successful implementation of ultrasound irradiation for the rapid synthesis of a novel series of 3-[1-(4-substituted-5-(aryldiazenyl)thiazol-2-yl) hydrazono)ethyl]-2Hchromen- 2-ones 5a-h, via reactions of 2-(1-(2-oxo-2H- chromen-3-yl)ethylidene) thiosemicarbazide (2) and the hydrazonoyl halides 3(4), was demonstrated. Also, a new series of 5-arylidene-2-(2-(1-(2-oxo-2H-chromen- 3-yl)ethylidene)hydrazinyl)thiazol- 4(5H)-ones 10a-d were synthesized from reaction of 2 with chloroacetic acid and different aldehydes. Moreover, reaction of 2-cyano-N'-(1-(2-oxo-2H-chromen-3-yl)ethylidene)- acetohydrazide (12) with substituted benzaldehydes gave the respective arylidene derivatives 13a-c under the conditions employed. The structures of the synthesized compounds were assigned based on elemental analyses and spectral data. Also, the cytototoxic activities of the thiazole derivative 5a was evaluated against HaCaT cells (human keratinocytes). It was found that compound 5a possess potent cytotoxic activity.