1403935-90-9

Basic information

• Product Name: 3-[1-(2-(4-phenyl-5-(p-tolyldiazenyl)thiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-one
• Synonyms: 3-[1-(2-(4-phenyl-5-(p-tolyldiazenyl)thiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-one
• CAS NO: 1403935-90-9
• Molecular Weight: 479.562
• Mol File: 1403935-90-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[1-(2-(4-phenyl-5-(p-tolyldiazenyl)thiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[1-(2-(4-phenyl-5-(p-tolyldiazenyl)thiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-one(1403935-90-9)
• EPA Substance Registry System: 3-[1-(2-(4-phenyl-5-(p-tolyldiazenyl)thiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-one(1403935-90-9)

Safety Data

• Hazardous Substances Data: 1403935-90-9(Hazardous Substances Data)

Upstream product

• 52831-78-4 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazine-1-carbothioamide 
• 59255-03-7 2-oxo-2-phenyl-N'-p-tolyl-acetohydrazonoyl bromide 
• 3949-36-8 3-acetylcoumarin 
• 1359132-58-3 3-(1-(2-(4-phenylthiazol-2-yl)hydrazono)ethyl)-2H-chromen-2-one 
• 106-49-0 p-toluidine 

Relevant articles and documents

A convenient ultrasound-promoted synthesis of some new thiazole derivatives bearing a coumarin nucleus and their cytotoxic activity

Successful implementation of ultrasound irradiation for the rapid synthesis of a novel series of 3-[1-(4-substituted-5-(aryldiazenyl)thiazol-2-yl) hydrazono)ethyl]-2Hchromen- 2-ones 5a-h, via reactions of 2-(1-(2-oxo-2H- chromen-3-yl)ethylidene) thiosemicarbazide (2) and the hydrazonoyl halides 3(4), was demonstrated. Also, a new series of 5-arylidene-2-(2-(1-(2-oxo-2H-chromen- 3-yl)ethylidene)hydrazinyl)thiazol- 4(5H)-ones 10a-d were synthesized from reaction of 2 with chloroacetic acid and different aldehydes. Moreover, reaction of 2-cyano-N'-(1-(2-oxo-2H-chromen-3-yl)ethylidene)- acetohydrazide (12) with substituted benzaldehydes gave the respective arylidene derivatives 13a-c under the conditions employed. The structures of the synthesized compounds were assigned based on elemental analyses and spectral data. Also, the cytototoxic activities of the thiazole derivative 5a was evaluated against HaCaT cells (human keratinocytes). It was found that compound 5a possess potent cytotoxic activity.