135923-97-6

Basic information

• Product Name: O⁴-(tert-Butyl) Hydrogen (R)-N²-<(Benzyloxy)carbonyl>-2-methylaspartate
• Synonyms: O⁴-(tert-Butyl) Hydrogen (R)-N²-<(Benzyloxy)carbonyl>-2-methylaspartate
• CAS NO: 135923-97-6
• Molecular Weight: 337.373
• Mol File: 135923-97-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: O⁴-(tert-Butyl) Hydrogen (R)-N²-<(Benzyloxy)carbonyl>-2-methylaspartate(CAS DataBase Reference)
• NIST Chemistry Reference: O⁴-(tert-Butyl) Hydrogen (R)-N²-<(Benzyloxy)carbonyl>-2-methylaspartate(135923-97-6)
• EPA Substance Registry System: O⁴-(tert-Butyl) Hydrogen (R)-N²-<(Benzyloxy)carbonyl>-2-methylaspartate(135923-97-6)

Safety Data

• Hazardous Substances Data: 135923-97-6(Hazardous Substances Data)

Upstream product

• 135923-92-1 (2S,4R)-3-<(Benzyloxy)carbonyl>-4-(<(tert-butyloxy)carbonyl>methyl)-4-methyl-2-phenyl-1,3-oxazolidin-5-one 
• 1142-20-7 N-Cbz-Ala 
• 135923-89-6 (2R,4S)-3-<(Benzyloxy)carbonyl>-4-(<(tert-butyloxy)carbonyl>methyl)-4-methyl-2-phenyl-1,3-oxazolidin-5-one 
• 135923-87-4 (2S,4R)-3-<(Benzyloxy)carbonyl>-4-methyl-2-phenyl-1,3-oxazolidin-5-one 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 171860-41-6 (S,S)-4-methyl-5-oxo-2-phenyl-oxazolidine-3-carboxylic acid benzyl ester 

Downstream Products

• 147108-45-0 O⁴-(tert-butyl) hydrogen (R)-2-methylaspartate 

Relevant articles and documents

ASPARAGINE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to compounds of formulas (A) and (I), pharmaceutically acceptable salts thereof, and solvates of any of them, pharmaceutical compositions comprising them, methods of preparation thereof, intermediate compounds useful for the preparation thereof, and methods of treatment or prophylaxis of diseases, in particular cancer, such as colorectal cancer, using these. (A) (I)

Versatile Stereoselective Synthesis of Completely Protected Trifunctional α-Methylated α-Amino Acids Starting from Alanine

A new route to completely protected α-methylated α-amino acids starting from alanine is described (see Scheme).These derivatives, which are obtained via base-catalyzed opening of the oxazolidinones (2S,4R)- and (2R,4S)-2, can be directly employed in pepti