135950-59-3Relevant articles and documents
in silico design, ADME prediction, molecular docking, synthesis of novel triazoles, indazoles & aminopyridines and in vitro evaluation of antitubercular activity
Triveni,Naresh Babu,Bhargav,Vijaya Jyothi
, p. 2713 - 2721 (2020/11/23)
To design and synthesize novel triazoles, indazoles and aminopyridines from various (thiophene-2-yl)prop-2-en-1-one derivatives as antitubercular leads by in silico and in vitro methods. in silco Drug design, ADME prediction and molecular docking studies
Selective Horner-Wittig/Nazarov vsKnoevenagel/Nazarov Reactions in the Synthesis of Biologically Active 3-Aryl-Substituted 1-Indanones
Szczesna, Dorota,Koprowski, Marek,Ró?ycka-Soko?owska, Ewa,Marciniak, Bernard,Ba?czewski, Piotr
supporting information, p. 113 - 116 (2016/12/26)
3-Aryl-1-indanones and a previously unknown group of 3-aryl-2-phosphoryl-1-indanones have been synthesized from β-ketophosphonates and aromatic aldehydes via corresponding chalcones, in a selective Horner-Wittig or Knoevenagel olefination, followed by a Nazarov cyclization. In preliminary tests, the final compounds and the intermediate chalcones revealed anticancer activity against HeLa and K562 at the μM level.
Inhibitory potential of some chalcones on cathepsins B, H and L
Garg, Shweta,Raghav, Neera
, p. 72937 - 72949 (2015/09/15)
Cathepsins, intracellular proteases, are known to be involved in a number of physiological processes such as degradation of extracellular proteins, prohormone processing, progressions of atherosclerosis etc. High levels of cathepsins have also been indica
