135959-07-8Relevant academic research and scientific papers
INDANE DERIVATIVES AS MGLUR7 MODULATORS
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Page/Page column 78; 79, (2017/08/21)
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a and R4b are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds of formula (I) are mGluR7 modulators.
COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION
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Page/Page column 155-156, (2012/08/08)
The present disclosure provides a series of compounds of the formula (I), which modulate β-amyloid peptide (β-ΑΡ) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-ΑΡ) production.
COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION
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Page/Page column 171, (2011/02/24)
The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Reactivity of Some 3-Substituted Derivatives of 2,6-Dihalogenopyridines Towards Potassium Amide in Liquid Ammonia .
Streef, J. W.,Hertog, H. J. den,Plas, H. C. van der
, p. 985 - 991 (2007/10/02)
Reactions of 2,6-dichloro-3-phenyl-, 2,6-dibromo-3-phenyl-, 2,6-dichloro-3-dimethylamino- and 2,6-dibromo-3-dimethylaminopyridine with potassium amide in liquid ammonia were investigated.Whereas 2,6-dichloro-3-phenylpyridine yields 4-amino-2-benzylpyrimidine, from 2,6-dibromo-3-phenylpyridine as a product of a novel ring fission 2-amino-1-cyano-1-phenyl-but-1-en-3-yne was isolated, together with 4-amino-6-bromo-3-phenylpyridine and 2,6-diamino-3-phenylpyridine.It was shown that neither 2-amino-6-bromo-3-phenyl- nor 6-amino-2-bromo-3-phenylpyridine are intermediates in the formation of the 2,6-diamino derivative, as these bromo compounds are transformed in the basic medium into 1,3-dicyano-1-phenylpropene.From both 2,6-dichloro-3-dimethylamino- and 2,6-dibromo-3-dimethylaminopyridine mixtures are obtained from which only 2-amino-1-cyano-1-dimethylamino-but-1-en-3-yne and 4-amino-6-halogeno-3-dimethylaminopyridine were isolated.Mechanisms for the reactions studied are proposed, i.e. a SN(ANRORC) mechanism for the aminodebromination of 2,6-dibromo-3-phenylpyridine into the corresponding 2,6-diamino compound.
