90765-41-6Relevant academic research and scientific papers
FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY
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Page/Page column 60; 61, (2019/03/17)
A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1 and MOF.
Efficient synthesis of α-aryl-/heteroaryl-substituted β-amino acids via Ni(II) complex through the Suzuki coupling reaction
Ding, Xiao,Ye, Deju,Liu, Fang,Deng, Guanghui,Liu, Guannan,Luo, Xiaomin,Jiang, Hualiang,Liu, Hong
supporting information; experimental part, p. 5656 - 5659 (2009/12/26)
(Chemical Equation Presented) We described a synthesis method by first using chlorotrimethylsilane as the activator to brominate the Ni(II) complex of the β-alanine Schiff's base [β-AlaNi(II)-PABA] 1 and developed it to prepare β-amino acids 5. The proced
Potential GABAB Receptor Antagonists. X* the Synthesis of Further Analogues of Baclofen, Phaclbfen and Saclofen
Prager, Rolf H.,Schafer, Karl
, p. 813 - 823 (2007/10/03)
In an attempt to obtain new compounds with binding activity at the GABAB receptor site, we report the synthesis of 3-amino-2-arylpropanoic acids, and the sulfonic, phosphonic and hydroxamic acid analogues. In addition, we report the synthesis of the isomer of phaclofen, 3-amino-1-(4-chlorophenyl)-propylphosphonic acid, and the higher homologue of baclofen, 5-amino-2-(4-chlorophenyl)pentanoic acid.
3-Amino-2-arylpropanoic acids by electrophilic substitution of 2-arylethylamines at the benzylic position
Simig,Schlosser
, p. 1963 - 1964 (2007/10/02)
A reaction sequence consisting of N-pivaloylation, lithiation at the benzylic position, carboxylation and deprotection allows to convert 2-arylethylamines into 3-amino-2-arylpropanoic acids with good yields.
