135970-65-9

Upstream product

• 6270-19-5 4-(oxiran-2-ylmethyl)morpholine 
• 121909-82-8 1-azido-2-hydroxy-3-morpholinopropane 
• 39849-45-1 1-amino-3-morpholin-4-yl-propan-2-ol 
• 135913-05-2 (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{(S)-1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-2-morpholin-4-yl-ethyl} ester 3-tert-butyl ester 
• 135913-03-0 (S)-2-Benzyloxycarbonylamino-4-(2-hydroxy-3-morpholin-4-yl-propylcarbamoyl)-butyric acid tert-butyl ester 

Downstream Products

• 135913-41-6 (S)-2-Benzyl-N-((2S,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide 
• 135970-67-1 [(S)-1-((2S,8S,11S,12R)-11-Cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

The synthesis of potent marcocyclic renin inhibitors

An efficient synthesis of a novel class of potent macrocylic renin inhibitors exemplified by compounds 1 and 2, which involves the marcocyclization of 8 and 9 as the key step, is described. The macrocyclic design of renin inhibitors 1 and 2 disclosed here