39849-45-1

Usage

Uses

Used in Organic Synthesis:
1-amino-3-morpholin-4-yl-propan-2-ol is used as a reagent in organic synthesis for its ability to participate in a range of chemical reactions due to the presence of both an amino and a hydroxy group. This makes it a valuable intermediate for the preparation of various organic compounds.
Used in Pharmaceutical Industry:
1-amino-3-morpholin-4-yl-propan-2-ol is used as a key intermediate in the synthesis of pharmaceuticals, leveraging its chemical properties to facilitate the creation of new drug molecules. Its potential biological activities and pharmacological properties are also under investigation, which could lead to its direct use in medicinal applications.
While the provided materials do not specify particular applications or industries beyond organic synthesis and pharmaceuticals, the compound's versatility suggests it may find use in other areas such as materials science, agrochemicals, or as a building block for other specialty chemicals, pending further research and development.

Upstream product

• 6270-19-5 4-(oxiran-2-ylmethyl)morpholine 
• 52900-07-9 N-morpholino-3-hydroxyazetidinium chloride 
• 50456-39-8 N-(2-hydroxy-3-morpholin-4-yl-propyl)-phthalimide 
• 121909-82-8 1-azido-2-hydroxy-3-morpholinopropane 

Downstream Products

• 135913-03-0 (S)-2-Benzyloxycarbonylamino-4-(2-hydroxy-3-morpholin-4-yl-propylcarbamoyl)-butyric acid tert-butyl ester 
• 135970-78-4 (S)-2-Benzyl-N-((2R,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide 
• 135913-41-6 (S)-2-Benzyl-N-((2S,8S,11S,12R)-11-cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-3-(2-methyl-propane-2-sulfonyl)-propionamide 
• 135970-68-2 [(S)-1-((2R,8S,11S,12R)-11-Cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 135970-67-1 [(S)-1-((2S,8S,11S,12R)-11-Cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 141395-91-7 (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{(R)-1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-2-morpholin-4-yl-ethyl} ester 3-tert-butyl ester 
• 135913-05-2 (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{(S)-1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-2-morpholin-4-yl-ethyl} ester 3-tert-butyl ester 
• 135970-66-0 ((2R,8S,11S,12R)-11-Cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-carbamic acid benzyl ester 
• 135970-65-9 ((2S,8S,11S,12R)-11-Cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-carbamic acid benzyl ester 
• 1245466-00-5 C₃₀H₃₄N₈O₈S₂ 
• 873002-83-6 benzoic acid 2-(5-benzoyl-1,3-dibenzyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylamino)-1-(morpholin-4-ylmethyl)ethyl ester 
• 873002-89-2 3-phenyl-propionic acid 2-[1,3-dimethyl-2,6-dioxo-5-(3-phenylphenylpropionyl)-1,2,3,6-tetrahydropyrimidin-4-ylamino]-1-(morpholin-4-ylmethyl)ethyl ester 
• 873002-77-8 benzoic acid 2-(5-benzoyl-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylamino)-1-(morpholin-4-ylmethyl)ethyl ester 

Relevant academic research and scientific papers

PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIES,THE PREPARATION AND THE PHARMCETICAL USE THEEOF

The invention provides new pyrrolo-nitrogenous heterocyclic derivatives represented by formula (I) or their salts, the preparation thereof, pharmaceutical compositions containing such derivatives and the use of such derivatives as therapeutic agents, especially as protein kinase inhibitors, wherein each substituent in formula (I) is same as defined in the description.

MORPHOLINYL CONTAINING BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION

The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I), a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereoc

Treatment of excessive osteolysis with indolinone compounds

Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.

3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as portein kinase inhibitors

The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Treatment of acute myeloid leukemia with indolinone compounds

A method of treating acute myeloid leukemia in patient positive for FLT-3-ITD is described. The treatment is accomplished by administration of a compound of Formula I or II as defined herein.

Reactions of derivatives of sulfamic acid with epoxides. 3.* reactions of 3-chloro-2-hydroxypropylsulfamates with amines and synthesis of 1,3-diamino-2-propanols

1,3-Diamino-2-propanols were prepared in high yields by reactions of potassium or sodium 3-chloro-2-hydroxypropylsulfamates with amines followed by acid hydrolysis of the 3-amino-2-hydroxypropylsulfamates that formed.

NEW RENIN-INHIBITORY OLIGOPEPTIDES, THEIR PREPARATION AND THEIR USE

Oligopeptides of formula (I): STR1 where R 1-R 5 are various organic groups, and A represents a group of formula--NH--or--(CH 2) n--, in which n represents an integer of from 1 to 3, have renin-inhibitory activity and are particularly suitable for oral administration. They may be prepared by condensing their component amino acids or lower oligopeptides using conventional peptide synthesis reactions.

The synthesis of potent marcocyclic renin inhibitors

An efficient synthesis of a novel class of potent macrocylic renin inhibitors exemplified by compounds 1 and 2, which involves the marcocyclization of 8 and 9 as the key step, is described. The macrocyclic design of renin inhibitors 1 and 2 disclosed here