135970-68-2

Upstream product

• 39849-45-1 1-amino-3-morpholin-4-yl-propan-2-ol 
• 135970-66-0 ((2R,8S,11S,12R)-11-Cyclohexylmethyl-12-hydroxy-2-morpholin-4-ylmethyl-5,9,13-trioxo-1-oxa-4,10-diaza-cyclotridec-8-yl)-carbamic acid benzyl ester 
• 135913-03-0 (S)-2-Benzyloxycarbonylamino-4-((R)-2-hydroxy-3-morpholin-4-yl-propylcarbamoyl)-butyric acid tert-butyl ester 
• 135913-03-0 (S)-2-Benzyloxycarbonylamino-4-(2-hydroxy-3-morpholin-4-yl-propylcarbamoyl)-butyric acid tert-butyl ester 
• 141395-85-9 (S)-1-Azido-3-morpholin-4-yl-propan-2-ol 
• 452105-38-3 (R)-1-Amino-3-(4-morpholinyl)-2-propanol 
• 141395-84-8 (2R)-(+)-N-(2,3-epoxypropyl)morpholine 
• 141395-91-7 (4S,5R)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 5-{(R)-1-[((S)-4-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-methyl]-2-morpholin-4-yl-ethyl} ester 3-tert-butyl ester 
• 121909-82-8 1-azido-2-hydroxy-3-morpholinopropane 
• 6270-19-5 4-(oxiran-2-ylmethyl)morpholine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Relevant academic research and scientific papers

The synthesis of potent marcocyclic renin inhibitors

An efficient synthesis of a novel class of potent macrocylic renin inhibitors exemplified by compounds 1 and 2, which involves the marcocyclization of 8 and 9 as the key step, is described. The macrocyclic design of renin inhibitors 1 and 2 disclosed here