1359711-06-0Relevant articles and documents
Synthesis of cis- and trans-(±)-3-mercaptoproline and pipecolic acid derivatives via thio-Michael addition
Gutiérrez, Alejandro,Osante, I?aki,Cativiela, Carlos
, p. 1661 - 1665 (2018)
The reactivity of 2,3-dehydroproline and 2,3-dehydropipecolic acid methyl ester derivatives with S-nucleophiles in the thio-Michael addition reaction has been explored. The addition of triphenylmethanethiol and subsequent trityl cleavage led to the corres
Diastereodivergent synthesis of 4-hydroxy-2,3-methanopipecolic acid derivatives as conformationally constrained homoserine analogues
Occhiato, Ernesto G.,Casini, Andrea,Guarna, Antonio,Scarpi, Dina
experimental part, p. 6544 - 6552 (2012/01/06)
A short, practical procedure for the diastereodivergent synthesis of cyclopropanated 4-hydroxypipecolic acid derivatives with high optical purity is reported. Key steps are the highly enantioselective lipase-catalyzed kinetic resolution and the stereosele