1359941-72-2

Upstream product

• 57600-03-0 4-phenyl-3-(pyridin-3-yl)-Δ²-1,2,4-triazoline-5-thione 
• 1359941-48-2 2-{[4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide 
• 332909-79-2 ethyl [(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl] acetate 
• 1359941-51-7 4-(4-methoxyphenyl)-1-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 

Relevant academic research and scientific papers

Synthesis and antimicrobial properties of new thiosemicarbazide, 1,2,4-triazole, and 1,3,4-thiadiazole derivatives of sulfanylacetic acid

1,2,4-triazole and 1,3,4-thiadiazole derivatives are still considered a viable lead structure for the synthesis of more efficient antimicrobial agents having a broad spectrum of activity. This study presents the synthesis and antimicrobial evaluation of a new series of substituted 1,2,4-triazole and 1,3,4-thiadiazole derivatives. Reaction of 4-phenyl-5-(pyridin-3-yl)-4H-1,2,4- triazole-3-thione with ethyl bromoacetate yields the corresponding ethyl acetate (1). In the subsequent reaction with 100% hydrazine hydrate, the hydrazide (2) was obtained, which was converted with isothiocyanates to new acyl derivatives of thiosemicarbazide (3a-l). The cyclization of these compounds in alkaline media resulted in the formation of new derivatives of 1,2,4-triazole (4a-i), whereas in acidic media new derivatives of 1,3,4-thiadiazole (5a,b,g) were obtained. All synthesized compounds were screened for their in vitro antimicrobial activities.