332909-79-2

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 57600-03-0 4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol 
• 105-36-2 ethyl bromoacetate 
• 57600-03-0 4-phenyl-3-(pyridin-3-yl)-Δ²-1,2,4-triazoline-5-thione 

Downstream Products

• 1359941-73-3 2-[amino-(4-chlorophenyl)]-5-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl) sulfanyl]methyl}-1,3,4-thiadiazole 
• 333418-51-2 [(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl] acetic acid 
• 1359941-74-4 4-carboxymethyl-5-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4H-1,2,4-triazole-3(2H)-thione 
• 1359941-75-5 5-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-2,5-dihydro-4H-1,2,4-triazole-3(2H)-thione 
• 1359941-51-7 4-(4-methoxyphenyl)-1-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 
• 1359941-48-2 2-{[4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide 
• 1359941-52-8 4-benzyl-1-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 
• 1359941-53-9 4-cyclohexyl-1-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 
• 1359941-54-0 4-(4-bromophenyl)-1-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 
• 1359941-55-1 4-ethyl-1-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 
• 1359941-56-2 4-(4-chlorophenyl)-1-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 
• 1359941-57-3 4-(4-methoxybenzyl)-1-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 
• 1359941-58-4 4-allyl-1-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 
• 1359941-72-2 2-[amino-(4-methoxyphenyl)]-5-{[(4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl) sulfanyl]methyl}-1,3,4-thiadiazole 

Relevant academic research and scientific papers

Alkylation of 1,2,4-triazole-3-thiols with haloalkanoic acid esters

Alkylation of 4,5-disubstituted 4H-1,2,4-triazole-3-thiols with methyl chloroformate and ethyl chloroacetate chemoselectively afforded the corresponding S-alkyl derivatives, whereas the alkylation of 5-benzyl-4-phenyl-4H-1,2,4-triazole-3-thiol with methyl 3-bromopropanoate gave an inseparable mixture of S- and N-alkylation products. Hydrazinolysis of S-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-yl) methyl carbonothioate involved anomalous cleavage with formation of the initial 4,5-disubstituted 1,2,4-triazole and methyl hydrazinecarboxylate.

Synthesis and Antimicrobial Evaluation of New Schiff Base Hydrazones Bearing 1,2,4-Triazole Moiety

This study presents the synthesis and spectral analysis of new Schiff base hydrazone derivatives. New compounds were prepared by the reaction of [(4-phenyl-5-substituted-4H-1,2,4-triazol-3-yl)sulfanyl] acetohydrazide with various aldehydes. The structures

Synthesis and antimicrobial properties of new thiosemicarbazide, 1,2,4-triazole, and 1,3,4-thiadiazole derivatives of sulfanylacetic acid

1,2,4-triazole and 1,3,4-thiadiazole derivatives are still considered a viable lead structure for the synthesis of more efficient antimicrobial agents having a broad spectrum of activity. This study presents the synthesis and antimicrobial evaluation of a new series of substituted 1,2,4-triazole and 1,3,4-thiadiazole derivatives. Reaction of 4-phenyl-5-(pyridin-3-yl)-4H-1,2,4- triazole-3-thione with ethyl bromoacetate yields the corresponding ethyl acetate (1). In the subsequent reaction with 100% hydrazine hydrate, the hydrazide (2) was obtained, which was converted with isothiocyanates to new acyl derivatives of thiosemicarbazide (3a-l). The cyclization of these compounds in alkaline media resulted in the formation of new derivatives of 1,2,4-triazole (4a-i), whereas in acidic media new derivatives of 1,3,4-thiadiazole (5a,b,g) were obtained. All synthesized compounds were screened for their in vitro antimicrobial activities.