1359945-70-2Relevant academic research and scientific papers
Enantioselective Ir-Catalyzed Allylic Alkylation of Racemic Allylic Alcohols with Malonates
Meng, Chun-Yan,Liang, Xiao,Wei, Kun,Yang, Yu-Rong
, p. 840 - 843 (2019)
Ir-catalyzed enantioselective allylic alkylation of branched racemic allylic alcohols with malonates is described. Enabled by Carreira's chiral Ir/(P, olefin) complex, the method described allows allylic substitution with various aromatic alcohols and mal
Bis(perfluoroalkyl) phosphino-oxazoline: A modular, stable, strongly π-accepting ligand for asymmetric catalysis
Hu, Zongjian,Li, Yuguang,Liu, Kai,Shen, Qilong
, p. 7957 - 7967 (2013/01/15)
A new class of stable, strongly π-accepting and modular bis-(perfluoroalkyl)-phosphine-oxazoline ligands (FOX) as CO mimics was prepared. It was demonstrated that these ligands, when coordinated to palladium catalysts, promote the asymmetric alkylation of monosubstituted allyl substrates with excellent regio- and enantioselectivity. Solid and solution structure analysis of the FOX-ligated Pd-allyl intermediate reveals that the combination of relative steric and strong trans influences presented by the P(CF 3)2 moiety gave rise to the excellent selectivity.
