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CAS

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1359967-83-1

5-acetyl-2-(3-(trifluoromethyl)phenylamino)benzoic acid methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1359967-83-1 Structure

  • Basic information

    1. Product Name: 5-acetyl-2-(3-(trifluoromethyl)phenylamino)benzoic acid methyl ester
    2. Synonyms: 5-acetyl-2-(3-(trifluoromethyl)phenylamino)benzoic acid methyl ester
    3. CAS NO:1359967-83-1
    4. Molecular Formula:
    5. Molecular Weight: 337.298
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1359967-83-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-acetyl-2-(3-(trifluoromethyl)phenylamino)benzoic acid methyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-acetyl-2-(3-(trifluoromethyl)phenylamino)benzoic acid methyl ester(1359967-83-1)
    11. EPA Substance Registry System: 5-acetyl-2-(3-(trifluoromethyl)phenylamino)benzoic acid methyl ester(1359967-83-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1359967-83-1(Hazardous Substances Data)

1359967-83-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1359967-83-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,9,9,6 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1359967-83:
(9*1)+(8*3)+(7*5)+(6*9)+(5*9)+(4*6)+(3*7)+(2*8)+(1*3)=231
231 % 10 = 1
So 1359967-83-1 is a valid CAS Registry Number.

1359967-83-1Downstream Products

1359967-83-1Relevant articles and documents

Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N -phenyl-aminobenzoates and their structure-activity relationships

Adeniji, Adegoke O.,Twenter, Barry M.,Byrns, Michael C.,Jin, Yi,Chen, Mo,Winkler, Jeffrey D.,Penning, Trevor M.

supporting information; experimental part, p. 2311 - 2323 (2012/05/04)

Aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) is overexpressed in castration resistant prostate cancer (CRPC) and is implicated in the intratumoral biosynthesis of testosterone and 5α-dihydrotestosterone. Selective AKR1C3 inhibitors are required because compounds should not inhibit the highly related AKR1C1 and AKR1C2 isoforms which are involved in the inactivation of 5α-dihydrotestosterone. NSAIDs, N-phenylanthranilates in particular, are potent but nonselective AKR1C3 inhibitors. Using flufenamic acid, 2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid, as lead compound, five classes of structural analogues were synthesized and evaluated for AKR1C3 inhibitory potency and selectivity. Structure-activity relationship (SAR) studies revealed that a meta-carboxylic acid group relative to the amine conferred pronounced AKR1C3 selectivity without loss of potency, while electron withdrawing groups on the phenylamino B-ring were optimal for AKR1C3 inhibition. Lead compounds did not inhibit COX-1 or COX-2 but blocked the AKR1C3 mediated production of testosterone in LNCaP-AKR1C3 cells. These compounds offer promising leads toward new therapeutics for CRPC.

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