343338-97-6Relevant academic research and scientific papers
Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
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Page/Page column 17, (2008/06/13)
Described herein are compositions and methods for preventing and/or treating skin diseases including, but not limited to, psoriasis and atopic dermatitis as well as providing anti-aging benefits which results in reduced appearance of wrinkles and aged ski
Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors
Cheng, Hengmiao,Lundy DeMello, Kristin M.,Li, Jin,Sakya, Subas M.,Ando, Kazuo,Kawamura,Kato, Tomoki,Rafka, Robert J.,Jaynes, Burton H.,Ziegler, Carl B.,Stevens, Rod,Lund, Lisa A.,Mann, Donald W.,Kilroy, Carolyn,Haven, Michelle L.,Nimz, Erik L.,Dutra, Jason K.,Li, Chao,Minich, Martha L.,Kolosko, Nicole L.,Petras, Carol,Silvia, Annette M.,Seibel, Scott B.
, p. 2076 - 2080 (2007/10/03)
The discovery of heteroaryl-phenyl-substituted pyrazole derivatives as canine selective COX-2 inhibitors is described. Structure-activity relationship (SAR) studies of this class of compounds led to the identification of compound 1 which demonstrated a ca
Synthesis and evaluation of a novel nonsteroidal-specific endothelial cell proliferation inhibitor
Schmidt, Jonathan M.,Tremblay, Gilles B.,Pagé, Martine,Mercure, Julie,Feher, Miklos,Dunn-Dufault, Robert,Peter, Markus G.,Redden, Peter R.
, p. 1289 - 1292 (2007/10/03)
The identification of agents with specific antiproliferative or cytostatic activity against endothelial cells has significant value for the treatment of pathologies associated with angiogenesis, including solid tumors. Here, we describe a novel substitute
Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents
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Page/Page column 53, (2008/06/13)
This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring
Dibenzo[c]chromen-6-one derivatives as anti-cancer agents
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, (2008/06/13)
Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines and endothelial cells and methods of synthesis are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of cancer through either
Non-steroidal estrogen receptor ligands
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, (2008/06/13)
Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyc
