136-26-5

Basic information

• Product Name: N,N-bis(2-hydroxyethyl)decan-1-amide
• Synonyms: N,N-bis(2-hydroxyethyl)decan-1-amide;CAPRAMIDE DEA;Capric diethanolamide;Decanamide, N,N-bis(2-hydroxyethyl)-;N,N-Bis(2-hydroxyethyl)capric amide;N,N-Bis(2-hydroxyethyl)caprinamide
• CAS NO: 136-26-5
• Molecular Formula: C₁₄H₂₉NO₃
• Molecular Weight: 259.38496
• EINECS: 205-234-9
• Mol File: 136-26-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 417.9 °C at 760 mmHg
• Flash Point: 206.5 °C
• Appearance: /
• Density: 1.001 g/cm³
• Vapor Pressure: 9.88E-09mmHg at 25°C
• Refractive Index: 1.481
• PKA: 14.13±0.10(Predicted)
• CAS DataBase Reference: N,N-bis(2-hydroxyethyl)decan-1-amide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(2-hydroxyethyl)decan-1-amide(136-26-5)
• EPA Substance Registry System: N,N-bis(2-hydroxyethyl)decan-1-amide(136-26-5)

Safety Data

• Hazardous Substances Data: 136-26-5(Hazardous Substances Data)

Usage

General Description

N,N-bis(2-hydroxyethyl)decan-1-amide, often abbreviated as BHE-D-1, is a specialty chemical compound that falls under the category of amides and anilides. It is known for its surfactant properties - substances that can reduce the surface tension of a liquid. This property is frequently utilized in the manufacturing of various products including detergents and emulsifiers. The decan-1-amide backbone gives it its specific structure and function. Meanwhile, its hydroxyethyl groups contribute to its hydrophilic (water-loving) properties, allowing it to mix well with water. The precise characteristics, functionality, and safe handling practices can vary, thus it is crucial to refer to its Material Safety Data Sheet (MSDS) provided by the manufacturer.

InChI:InChI=1/C14H29NO3/c1-2-3-4-5-6-7-8-9-14(18)15(10-12-16)11-13-17/h16-17H,2-13H2,1H3

Synthetic route

decanoic acid ethyl ester (110-38-3) + 2,2'-iminobis[ethanol] (111-42-2) → N,N-bis-(2-hydroxy-ethyl)-decanamide (136-26-5)

Conditions	Yield
at 160℃;

1-decanoic acid (334-48-5) + 2,2'-iminobis[ethanol] (111-42-2) → N,N-bis-(2-hydroxy-ethyl)-decanamide (136-26-5)

Conditions	Yield
Stage #1: 1-decanoic acid; 2,2'-iminobis[ethanol] With benzotriazol-1-ol; triethylamine In dichloromethane for 0.25h; Cooling with ice; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Cooling with ice;

N,N-bis-(2-hydroxy-ethyl)-decanamide (136-26-5) + epichlorohydrin (106-89-8) → C20H37NO5 (1421857-90-0)

Conditions	Yield
With tetrabutyl-ammonium chloride; sodium hydroxide In water at 0 - 20℃; for 12.5h;

Upstream product

• 334-48-5 1-decanoic acid 
• 111-42-2 2,2'-iminobis[ethanol] 
• 110-38-3 decanoic acid ethyl ester 

Relevant articles and documents

Low molecular weight PEI-based biodegradable lipopolymers as gene delivery vectors

Non-viral gene vectors play an important role in the development of gene therapy. In this report, different hydrophobic chains were introduced into low molecular weight (LMW) PEI-based biodegradable oligomers to form a series of lipopolymers (LPs), and their structure-activity relationships were studied. Results revealed that the nine polymers can condense plasmid DNA well to form nanoparticles with appropriate sizes (120-250 nm) and positive zeta-potentials (+25-40 V). In vitro experiments were carried out and it was found that LP2 showed much higher transfection efficiency both in the presence and in the absence of serum under the polymer/DNA weight ratio of 0.8 in A549 cells.