1360056-32-1

Basic information

• Product Name: 4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzamide
• Synonyms: 4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzamide
• CAS NO: 1360056-32-1
• Molecular Weight: 220.246
• Mol File: 1360056-32-1.mol

Chemical Properties

• CAS DataBase Reference: 4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzamide(1360056-32-1)
• EPA Substance Registry System: 4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzamide(1360056-32-1)

Safety Data

• Hazardous Substances Data: 1360056-32-1(Hazardous Substances Data)

Upstream product

• 79538-29-7 2,4,6-trifluorobenzoyl chloride 
• 1360056-30-9 2-(4-(2-cyanoporopyl-2-yl)-2-fluoro-6-methylphenyl)-3,4,4-trimethyl-4,5-dihydro-1,3-oxazole-3-ium iodide 
• 1360056-31-0 4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzoic acid 
• 1360056-29-6 2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile 
• 1360056-28-5 2-(2,4-difluoro-6-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 1360056-27-4 4,4-dimethyl-2-(2,4,6-trifluorophenyl)-4,5-dihydro-1,3-oxazole 
• 1360056-26-3 2,4,6-trifluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)benzamide 
• 28314-80-9 2,4,6-trifluorobenzoic acid 

Downstream Products

• 1360056-33-2 4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide 
• 1360055-16-8 2-[8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile 
• 1360056-36-5 2-[8-fluoro-2-(2-formyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-1-oxo-1,2-dihydro-isoquinolin-6-yl]-2-methyl-propionitrile 
• 1360056-35-4 2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile 
• 1360057-32-4 2-chloro-6-[8-fluoro-6-(2-fluoro-1,1-dimethyl-ethyl)-1-oxo-1H-isoquinolin-2-yl]-benzaldehyde 
• 1360055-72-6 2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile 
• 1612853-60-7 2-(2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-formylphenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile 

Relevant articles and documents

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses the Btk inhibitor compounds 6-tert-Butyl-8-fluoro-2-{3- hydroxymethyl-4-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-6-ylamino)- 6-oxo-1,6-dihydro-pyridazin-3-yl]-pyridin-2-yl}-2H-phthalazin-1-one, 2-(2-{3-[5-(5-Azetidin-1- ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-2- hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile, and 6-tert-Butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxy-ethylamino)-methyl]-pyridin-2- ylamino}-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one, formulations thereof, and methods of treatment of asthma, as described herein.

Inhibitors of Bruton's Tyrosine Kinase

This application discloses 6-(2-Hydroxymethyl-phenyl)-2-methyl-2H-pyridazin-3-one derivatives according to generic Formula I: wherein, variables X, R, and Y4, are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.