1360081-75-9Relevant academic research and scientific papers
Stereoselective synthesis of both tetrahydropyran rings of the antitumor macrolide, (-)-lasonolide A
Ghosh, Arun K.,Ren, Guo-Bao
, p. 2559 - 2565 (2012)
Stereoselective syntheses of both functionalized tetrahydropyran subunits of (-)-lasonolide A are described. These tetrahydropyran rings were constructed using catalytic asymmetric hetero Diels-Alder reactions as the key steps. The C22 quaternary stereocenter present in the upper tetrahydropyran ring was constructed by a stereoselective alkylation, and the C9 hydroxy stereochemistry of the bottom tetrahydropyran was constructed by a stereoselective epoxidation followed by a regioselective epoxide opening reaction.
