136010-43-0Relevant academic research and scientific papers
An efficient process for the synthesis of renin inhibitor, ABT-517
Singam, Pulla Reddy,Bradshaw, Curt W.,Menzia, Jerome A.,Narayanan,Rockway, Todd W.,Welch, Noel,Tien, Jien-Heh J.
, p. 2751 - 2756 (2007/10/03)
An efficient process for the preparation of renin inhibitor, ABT-517 is described. The process avoids solvent extractions or chromatographic purfications and is used on multi-kilogram scale.
1,2,3-Trisubstituted Cyclopropanes as Conformationally Restricted Peptide Isosteres: Application to the Design and Synthesis of Novel Renin Inhibitors
Martin, Stephen F.,Austin, Richard E.,Oalmann, Christopher J.,Baker, William R.,Condon, Stephen L.,et al.
, p. 1710 - 1721 (2007/10/02)
The 1,2,3-trisubstituted cyclopropanes 6 and 7 are the first members of a novel class of isosteric replacements for peptide linkages that are more generally represented by the dipeptide mimics 2 and 3.These unique peptide surrogates are specifically desig
