136015-43-5Relevant academic research and scientific papers
Synthesis and Inhibitory Mechanisms of Phospholipase A2 Inhibitors
Katsumura,Iwama,Inagaki,Fujii,Ikeda
, p. 225 - 229 (2007/10/03)
Two types of Phospholipase A2 (PLA2) inhibitor were synthesized, one of which was a terpenoid having unsaturated aldehyde, and the other was a cyclic phospholipid analog. The inhibitory mechanisms of each compound were proposed. Thus, the former may irreversibly modify an interfacial recognition site, and the latter competitively binds to the catalytic site of PLA2 with the mode similar to that of the genuine substrate.
Synthesis of Optically Pure 4-Hydroxymethyloxazolidinone as Chiral Serinol Synthon from Glycidol
Katsumura, Shigeo,Kondo, Akihiro,Han, Quingjun
, p. 1245 - 1248 (2007/10/02)
Optically pure 3-benzyl-4-hydroxymethyl-2-oxazolidinone and 4-benzoyloxymethyl-2-oxazolidinone as chiral serinol synthons were synthesized from optically active glycidol by intramolecular cyclization via 2,3-epoxycarbamates with strict SN2 beha
