136031-36-2

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 99463-48-6 methyl syn-(2,2-di-t.butyl-4-(3',4'-mrthylenedioxyphenyl)-2-sila-1,3-dioxan-5-yl)-acetate 
• 135965-95-6 (2S,3S)-2-((4S,5R)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-3-(1-ethoxy-ethoxy)-3-(3,4,5-trimethoxy-phenyl)-propionic acid methyl ester 
• 136031-31-7 (3S,4R)-4-(2-Benzo[1,3]dioxol-5-yl-[1,3]dithian-2-yl)-3-[(S)-hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-dihydro-furan-2-one 
• 135965-94-5 (3S,4R)-4-(Benzo[1,3]dioxole-5-carbonyl)-3-[(S)-(1-ethoxy-ethoxy)-(3,4,5-trimethoxy-phenyl)-methyl]-dihydro-furan-2-one 
• 135965-89-8 (3S,4R)-4-((S)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-3-[(S)-(1-ethoxy-ethoxy)-(3,4,5-trimethoxy-phenyl)-methyl]-dihydro-furan-2-one 
• 135965-93-4 (3S,4R)-4-(Benzo[1,3]dioxole-5-carbonyl)-3-[(S)-hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-dihydro-furan-2-one 
• 85272-31-7 di-tert-butylsilyl bis(trifluoromethanesulfonate) 
• 108763-81-1 3-(2',2'-di-t.butyl-r-4'-(3,4-methylenedioxyphenyl)-2'-sila-1',3'-dioxane-c-5'-yl)-propane-1,2-diol 
• 108763-85-5 ((4R,5S)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-acetaldehyde 
• 99463-47-5 ((4R,5S)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-acetic acid 
• 99463-43-1 (R)-2-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-1-(2-thioxo-thiazolidin-3-yl)-pent-4-en-1-one 
• 99463-46-4 syn-5-allyl-2,2-di-t.butyl-4-(3',4'-methylenedioxyphenyl)-2-sila-1,3-dioxane 
• 99463-44-2 syn methyl 2-(hydroxy-(3',4'-methylenedioxyphenyl)-methyl)-4-pentenoate 

Downstream Products

• 99463-50-0 4-Benzo[1,3]dioxol-5-yl-3-hydroxymethyl-5,6,7-trimethoxy-3,4-dihydro-naphthalene-2-carboxylic acid methyl ester 
• 99463-52-2 5-Benzo[1,3]dioxol-5-yl-4-(di-tert-butyl-hydroxy-silanyloxymethyl)-2-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan-3-carboxylic acid methyl ester 
• 99463-53-3 (4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid methyl ester 
• 99463-53-3 (4aS,5S,6R,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid methyl ester 
• 99463-53-3 (4aS,5R,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid methyl ester 
• 4375-07-9 epipodophyllotoxin 
• 136031-37-3 (4aR,5R,6R,11bS)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Enantioselective Total Synthesis of (-)-Epipodophyllotoxin and (-)-Podophyllotoxin

An enantioselective total synthesis of (-)-epipodophyllotoxin (2) and hence of (-)-podophyllotoxin (1) is described, involving as key steps a conjugate addition on butenolide 13 as the chiral template, a stereoselective aldol condensation on 11a and a ste

TOTAL SYNTHESIS OF (+/-)-PODOPHYLLOTOXIN AND (+/-)-EPIPODOPHYLLOTOXIN

A novel approach to (+/-)-epipodophyllotoxin (2c) and hence also to (+/-)-podophyllotoxin (1c) is described, involving as a key-step the stereoselective ring closure of the TMS-ester derived from 17a to the tetralin derivative 30c with mesyl chloride.

TOTAL SYNTHESIS OF (+/-)-PODOPHYLLOTOXIN AND (+/-)-EPIPODOPHYLLOTOXIN.

A novel approach to (+/-)-epipodophyllotoxin (2) and hence also (+/-)-podophyllotoxin (1) is described, involving as a key-step the stereoselective ring closure of the TMS-ester derived from 14a to the tetralin derivative 15 with mesyl chloride.