136032-73-0Relevant academic research and scientific papers
ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS
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Paragraph 0696, (2016/08/10)
The disclosure provides compounds and pharmaceutical compositions of aryloxyacetylindoles compounds and analogs useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds of general Formula (I) (I) or a pharmaceutically acceptable salt or prodrug thereof. Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a subject, including Pseudomonas aeruginosa infections, are also provided by the disclosure.
Synthesis of the revised structure of acortatarin A
Geng, Hui Min,Stubbing, Louise A.,Li-Yang Chen, Jack,Furkert, Daniel P.,Brimble, Margaret A.
, p. 6227 - 6241 (2015/03/30)
A novel Maillard-type condensation between a primary amine derived from D-mannitol and a dihydropyranone, was used as a key step to access the unusual morpholine-spiroketal acortatarin A. The synthetic approach also enabled access to a C-2 analogue of acortatarin A, and can be used for the synthesis of related 2-formylpyrrole natural products.
A convergent approach for the total synthesis of the α-glucosidase inhibitor (-)-panaxjapyne-C
Sathish Reddy,Gangadhar,Srihari
, p. 1524 - 1530 (2013/12/04)
The stereoselective total synthesis of (-)-panaxjapyne-C was accomplished in a convergent fashion. The synthesis utilizes the readily available enantiomers l-(+)-diethyltartrate and d-(-)-diethyltartrate and involves a Cadiot-Chodkiewicz coupling reaction, and an Ohira-Bestmann reaction as the key steps.
A convergent synthesis of the 2-formylpyrrole spiroketal natural product acortatarin A
Geng, Huimin,Chen, Jack L.Y.,Furkert, Danielp.,Jiang, Shende,Brimble, Margaret A.
, p. 855 - 858 (2012/05/20)
A concise and flexible synthesis of the morpholine-spiroketal natural product acortatarin A, isolated from the traditional Chinese medicine Acorus tatarinowii, is reported. The key step involves a Maillard-type condensation of an amine derived from d-mannitol with a dihydropyranone. The approach also enables access to analogues of acortatarin A for biological evaluation and can be applied to the synthesis of related 2-formylpyrrole natural products. Georg Thieme Verlag Stuttgart . New York.
Assembly of the southern macrocyclic half of (+)-spirastrellolide a through cyclic acetal tethered ring-closing metathesis and 1,3-anti-mukaiyama-aldol
Tang, Yu,Yang, Jin-Haek,Liu, Jia,Wang, Chao-Chao,Lv, Ming-Can,Wu, Yi-Biao,Yu, Xue-Liang,Ko, Changhong,Hsung, Richard P.
, p. 565 - 598 (2013/08/23)
We describe herein details of our efforts in syntheses of A-ring and BC-ring of (+)-spirastrellolide A. While the former would constitute a facile 12-step synthetic endeavor starting from 1,5-pentanediol, the latter would showcase a cyclic acetal-tethered
Baylis-Hillman reaction based flexible strategy for the synthesis of gabosine I, gabosine G, epi-gabosine i and carba l-pentose
Radha Krishna, Palakodety,Kadiyala, Raghu Ram
scheme or table, p. 744 - 747 (2012/03/08)
A combination of diastereoselective Baylis-Hillman reaction and RCM reaction set is used as the flexible strategy for the ready access to cyclohexenoid and cyclopentenoid skeletons.
Total Synthesis of Sphingofungin F Based on Chiral Tricyclic Iminolactone
Gan, Feng-Feng,Yang, Shao-Bo,Luo, Yong-Chun,Yang, Wan-Bang,Xu, Peng-Fei
supporting information; experimental part, p. 2737 - 2740 (2010/07/08)
A new, efficient synthesis of sphingofungin F has been accomplished with 10.4% overall yield in 15 steps. The salient features of the synthesis are the utilization of methyl tricyclic iminolactone 3 for the asymmetric aldol reaction as a key step to intro
Synthesis of the C1-C23 fragment of spirastrellolide A
Yang, Jin-Haek,Liu, Jia,Hsung, Richard P.
supporting information; experimental part, p. 2525 - 2528 (2009/05/27)
(Chemical Equation Presented) Synthesis of the C1-C23 fragment in spirastrellolide A is described, featuring a cyclic acetal-tethered RCM for stereoselective constructions of spiroketal, and a 1,3-anti aldol involving methyl ketone enolate and Mukaiyama c
Nitrostated and nitrosylated prostaglandins, compositions and methods of use
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Page/Page column 32-33, (2008/06/13)
The present invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The present invention also provides novel compositions comprising at least one prostaglandin and at least one S-nitrosothiol compound, and, optionally, at least one vasoactive agent. The prostaglandin is preferably a prostaglandin E1 compound, more preferably alprostadil, and the S-nitrosothiol compound is preferably S-nitrosoglutathione. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing cerebrovascular disorders, cardiovascular disorders, benign prostatic hyperplasia (BPH), glaucoma, peptic ulcers or for inducing abortions. The compounds and/or compositions of the present invention can also be provided in the form of a pharmaceutical kit.
O-directed free-radical hydrostannations of propargyl ethers, acetals, and alcohols with Ph3SnH and Et3B
Dimopoulos, Paschalis,Athlan, Audrey,Manaviazar, Soraya,George, Jonathan,Walters, Marcus,Lazarides, Linos,Aliev, Abil E.,Hale, Karl J.
, p. 5369 - 5372 (2007/10/03)
(Chemical Equation Presented) The O-directed hydrostannation of various propargyloxy substrates is reported with Ph3SnH/Et3B.
