1360364-21-1

Basic information

• Product Name: tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate
• Synonyms: tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate;tert-Butyl hexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carboxylate;Pyrrolo[3,4-b]-1,4-oxazine-6(2H)-carboxylic acid, hexahydro-, 1,1-dimethylethyl ester;Hexahydro-pyrrolo[3,4-b][1,4]oxazine-6-carboxylic acid tert-butyl ester;tert-Butyl 3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazine-6-carboxylate
• CAS NO: 1360364-21-1
• Molecular Formula: C₁₁H₂₀N₂O₃
• Molecular Weight: 228.2881
• Mol File: 1360364-21-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 324.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.108±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.26±0.20(Predicted)
• CAS DataBase Reference: tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate(1360364-21-1)
• EPA Substance Registry System: tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate(1360364-21-1)

Safety Data

• Hazardous Substances Data: 1360364-21-1(Hazardous Substances Data)

Usage

Description

Tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate is a carboxylate ester derivative with the molecular formula C14H25NO3. It features a unique structure comprising a fused pyrrolidine and morpholine ring system, which endows it with potential for interactions with biological targets. This chemical compound is commonly utilized in pharmaceutical research as a building block for the synthesis of various molecules, particularly for the development of potential drug candidates.

Uses

Used in Pharmaceutical Research:
Tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate is used as a building block for the synthesis of various molecules in pharmaceutical research. Its unique structure allows it to be a versatile component in the development of potential drug candidates.
Used in Drug Discovery and Development:
Due to its diverse chemical properties, tert-butyl octahydrolo[3,4-b]morpholine-6-carboxylate is studied for its potential applications in drug discovery and development. Its ability to interact with biological targets makes it a promising candidate for the creation of new therapeutic agents.

Upstream product

• 1358783-16-0 tert-butyl 3-bromo-4-{2-[(4-methylbenzenesulfonyl)oxy]-ethoxy}pyrrolidine-1-carboxylate 
• 1358783-14-8 3-bromo-4-(2-hydroxyethoxy)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 1358783-18-2 hexahydro-4-benzyl-pyrrolo[3,4-b]-1,4-oxazin-6 (2H)-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 775251-20-2 4-methyl-3,4a,5,6,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazine 

Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

4-quinazoline amine derivatives and their use

A 4-quinazoline amine derivative as represented by formula (1), a pharmaceutical composition comprising the derivative, and an application thereof in preparing medicine for curing cancer. The cancer is a drug-resistant cancer, preferably a cancer resisting an EGFR reversible inhibitor, and more preferably, a cancer resisting gefitinib, erlotinib or lapatinib; alternatively, the cancer carries EGFR mutation.