136040-90-9Relevant academic research and scientific papers
Synthesis of Unprotected Spirocyclic β-Prolines and β-Homoprolines by Rh-Catalyzed C-H Insertion
Espinosa, Miguel,Noda, Hidetoshi,Shibasaki, Masakatsu
, p. 9296 - 9299 (2019)
A series of unprotected spirocyclic β-prolines and β-homoprolines are prepared by Rh-catalyzed C-H insertion. The key intermediate, a Rh nitrenoid, is generated by the N-O bond cleavage of a substituted isoxazolidin-5-one. The reaction proceeds on a gram scale with a catalyst loading of as little as 0.1 mol %, affording spirocyclic β-amino acids that are otherwise difficult to obtain. The building blocks prepared in this work will likely find applications in medicinal chemistry.
Multi-catalysis cascade reactions based on the methoxycarbonylketene platform: Diversity-oriented synthesis of functionalized non-symmetrical malonates for agrochemicals and pharmaceuticals
Ramachary, Dhevalapally B.,Venkaiah, Chintalapudi,Reddy, Y. Vijayendar,Kishor, Mamillapalli
supporting information; scheme or table, p. 2053 - 2062 (2009/09/05)
In this paper we describe new multi-catalysis cascade (MCC) reactions for the one-pot synthesis of highly functionalized non-symmetrical malonates. These metal-free reactions are either five-step (olefination/hydrogenation/alkylation/ ketenization/esterif
