217654-79-0

Upstream product

• 3377-21-7 dimethyl 2-methylenemalonate 
• 24371-94-6 cyclohexylmercury chloride 
• 186581-53-3 diazomethane 
• 136040-90-9 5-(cyclohexylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 100-51-6 benzyl alcohol 

Downstream Products

• 944163-58-0 dimethyl {(E)-4-[(tert-butyldimethylsilyl)oxy]but-2-en-1-yl}(cyclohexylmethyl)malonate 
• 1211006-06-2 dimethyl 2-(cyclohexylmethyl)-2-ethylmalonate 
• 944164-06-1 (E)-5-(cyclohexylmethyl)-6-hydroxy-5-(hydroxymethyl)hex-2-en-1-yl methyl carbonate 
• 944163-88-6 (E)-5-(cyclohexylmethyl)-5-(hydroxymethyl)hex-2-ene-1,6-diol 
• 944163-71-7 2-{(E)-4-[(tert-butyldimethylsilyl)oxy]but-2-en-1-yl}-2-(cyclohexylmethyl)propane-1,3-diol 

Relevant academic research and scientific papers

Multi-catalysis cascade reactions based on the methoxycarbonylketene platform: Diversity-oriented synthesis of functionalized non-symmetrical malonates for agrochemicals and pharmaceuticals

In this paper we describe new multi-catalysis cascade (MCC) reactions for the one-pot synthesis of highly functionalized non-symmetrical malonates. These metal-free reactions are either five-step (olefination/hydrogenation/alkylation/ ketenization/esterif

On the cis-Effect of Radical Addition Reactions at Alkenes

The trans-alkenes 2e - h react faster with cyclohexyl radicals than the cis-alkenes 3e - h (Table 1).Radical addition reactions at alkylidenemalonic esters 1 show that this cis-effect increases with the bulkyness of the substituents (Table 1).However, the difference in the reactivity between trans- and cis-alkenes exerts no effect on the regioselectivity (Table 3).It is concluded that the reason for the cis-effect is a twisting of the ?-system that influences the reactivity of both vinylic C-atoms to the same extent.