1360445-06-2Relevant academic research and scientific papers
Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity
Praveen Kumar, Vemula,Gajendra Reddy,Vo, Duc Duy,Chakravarty, Sumana,Chandrasekhar, Srivari,Grée, René
, p. 1439 - 1444 (2012/03/26)
A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5′-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity.
