13605-37-3

Upstream product

• 17639-93-9 2-chloro-propionic acid methyl ester 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 776-99-8 3,4-dimethoxyphenylacetone 
• 173481-88-4 methyl 4-acetoxy-4-(3,4-dimethoxyphenyl)-2-methoxycarbonyl-3-methyl-butenoate 
• 173481-89-5 4-(3,4-dimethoxyphenyl)-2-methoxycarbonyl-3-methyl-buten-4-olide 
• 38007-20-4 1-acetoxy-1-(3,4-dimethoxy-phenyl)-acetone 

Relevant academic research and scientific papers

Total synthesis of (±)-porosin, a neolignan from Ocotea porosa and Urbanodendron verrucosum (Lauraceae)

Veratraldehyde was condensed with methyl 2-chloropropanoate to give a glycidic ester. This was hydrolyzed with aqueous sodium hydroxide and the resulting sodium salt was treated with lead(IV) tetraacetate to give 1- acetoxy-1-(3,4-dimethoxyphenyl)propon-2

Development of a robust and practical process for the Darzens condensation and α,β-epoxide rearrangement: Scope and limitations of the methodology

A practical and robust process for the Darzens condensation of substituted benzaldehydes and subsequent α,β-epoxy rearrangement is reported. The process developed is both amenable to large scale and parallel synthesis. While electron-poor benzaldehydes gave mixtures of aryl ketones and 2-substituted aryl ketones in mediocre to low yields, electron-rich benzaldehydes were found to react in high yields with complete regioselectivity to form 2-substituted aryl ketones. Georg Thieme Verlag Stuttgart.