1360558-91-3Relevant academic research and scientific papers
Heteromultivalent Glycooligomers as Mimetics of Blood Group Antigens
Bücher, Katharina S.,Konietzny, Patrick B.,Snyder, Nicole L.,Hartmann, Laura
, p. 3301 - 3309 (2019/02/14)
Precision glycomacromolecules have proven to be important tools for the investigation of multivalent carbohydrate–lectin interactions by presenting multiple glycan epitopes on a highly-defined synthetic scaffold. Herein, we present a new strategy for the versatile assembly of heteromultivalent glycomacromolecules that contain different carbohydrate motifs in proximity within the side chains. A new building block suitable for the solid-phase polymer synthesis of precision glycomacromolecules was developed with a branching point in the side chain that bears a free alkyne and a TIPS-protected alkyne moiety, which enables the subsequent attachment of different carbohydrate motifs by on-resin copper-mediated azide–alkyne cycloaddition reactions. Applying this synthetic strategy, heteromultivalent glycooligomers presenting fragments of histo-blood group antigens and human milk oligosaccharides were synthesized and tested for their binding behavior towards bacterial lectin LecB.
A rational design for the directed helicity change of polyacetylene using dynamic rotaxane mobility by means of through-space chirality transfer
Ishiwari, Fumitaka,Fukasawa, Kei-Ichiro,Sato, Takashi,Nakazono, Kazuko,Koyama, Yasuhito,Takata, Toshikazu
, p. 12067 - 12075 (2011/11/14)
Directed helicity control of a polyacetylene dynamic helix was achieved by hybridization with a rotaxane skeleton placed on the side chain. Rotaxane-tethering phenylacetylene monomers were synthesized in good yields by the ester end-capping of pseudorotax
