Cas 1360568-55-3,N-(6-bromobenzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide

1360568-55-3

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Basic information

Product Name: N-(6-bromobenzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide
Synonyms: N-(6-bromobenzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide
CAS NO:1360568-55-3
Molecular Formula:
Molecular Weight: 421.315
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: N-(6-bromobenzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide(CAS DataBase Reference)
NIST Chemistry Reference: N-(6-bromobenzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide(1360568-55-3)
EPA Substance Registry System: N-(6-bromobenzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide(1360568-55-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1360568-55-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1360568-55-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,0,5,6 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1360568-55:
(9*1)+(8*3)+(7*6)+(6*0)+(5*5)+(4*6)+(3*8)+(2*5)+(1*5)=163
163 % 10 = 3
So 1360568-55-3 is a valid CAS Registry Number.

1360568-55-3Upstream product

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1360568-55-3Relevant academic research and scientific papers

Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis

Takemoto, Yasushi,Kadota, Shin,Minami, Itsunari,Otsuka, Shinya,Okuda, Satoshi,Abo, Masahiro,Punzalan, Louvy Lynn,Shen, Yan,Shiba, Yuji,Uesugi, Motonari

, p. 21824 - 21831 (2021)

KY02111 is a widely used small molecule that boosts cardiomyogenesis of the mesoderm cells derived from pluripotent stem cells, yet its molecular mechanism of action remains elusive. The present study resolves the initially perplexing effects of KY02111 on Wnt signaling and subsequently identifies squalene synthase (SQS) as a molecular target of KY02111 and its optimized version, KY-I. By disrupting the interaction of SQS with cardiac ER-membrane protein TMEM43, KY02111 impairs TGFβ signaling, but not Wnt signaling, and thereby recapitulates the clinical mutation of TMEM43 that causes arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited heart disease that involves a substitution of myocardium with fatty tissue. These findings reveal a heretofore undescribed role of SQS in TGFβ signaling and cardiomyogenesis. KY02111 may find its use in ARVC modeling as well as serve as a chemical tool for studying TGFβ/SMAD signaling.

PLURIPOTENT STEM CELL CARDIOMYOCYTE DIFFERENTIATION-PROMOTING AGENT

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Paragraph 0079, (2013/07/25)

The present invention relates to a composition for promoting differentiation of pluripotent stem cells into cardiac muscle cells, and a method for inducing differentiation of pluripotent stem cells into cardiac muscle cells and a method for preparing cardiac muscle cells.

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