136057-30-2

Upstream product

• 6456-74-2 Glycine tert-butyl ester 
• 136057-22-2 (R)-4-{3-[4-(2-Carboxy-ethyl)-phenoxy]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1200-07-3 trans-4-bromocinnamic acid 
• 25698-27-5 (R)-3-hydroxyphenylglycine 
• 136057-21-1 (R)-4-{3-[4-(2-Methoxycarbonyl-ethyl)-phenoxy]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 136057-20-0 (R)-4-{3-[4-((E)-2-Methoxycarbonyl-vinyl)-phenoxy]-phenyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 136057-18-6 (R)-3-hydroxyphenylglycine methyl ester hydrochloride 
• 136057-19-7 N-tert-butoxycarbonyl-2,2'-dimethyl-4-(3-hydroxyphenyl)-1,3-oxazolidine 
• 136083-50-6 N-tert-butoxycarbonyl-2-hydroxy-1-(3-hydroxyphenyl)-ethylamine 
• 130633-31-7 (R)-N-tert-butoxycarbonyl-3-hydroxyphenylglycine methyl ester 
• 3650-78-0 methyl (E)-4-bromocinnamate 
• 16881-32-6 tert-butyl N-(benzyloxycarbonyl)glycinate 

Downstream Products

• 136057-31-3 (3-{4-[3-((R)-1-Amino-2-hydroxy-ethyl)-phenoxy]-phenyl}-propionylamino)-acetic acid; hydrochloride 

Relevant academic research and scientific papers

An Approach to a Synthetic Carboxylate-binding Pocket Based on β-Avoparcin

An approach to a macrocyclic lactam designed to bind to a carboxylate anion is described.The diaryl ether 8 was synthesised by Ullmann coupling of the protected 3-hydroxyphenylglycine derivative 7 and (E)-4-bromocinnamic acid methyl ester.Elaboration of an optically pure (R)-tyrosine synthon was achieved by transfer of electrophilic azide to the N-acyl oxazolidinone 12.The synthesis of a model system is also described.