1360574-65-7

Upstream product

• 64695-84-7 2-bromo-4,5-difluorobenzoic acid 
• 1360574-64-6 C₂₉H₃₀ClF₅N₂O₅ 
• 1266728-02-2 tert-butyl (1R,3'S)-3'-[(cyclopropylamino)carbonyl]-5,6-difluoro-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 
• 1266727-97-2 tert-butyl (1R,3'S)-3'-[(cyclopropylamino)carbonyl]-5,6-difluoro-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate 
• 1266727-99-4 1-tert-butyl 3-ethyl 4-[2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-difluorophenyl]-5,6-dihydro-1,3(2H)-pyridinedicarboxylate 
• 1266727-98-3 [(2-bromo-4,5-difluorobenzyl)oxy](tert-butyl)dimethylsilane 
• 261763-22-8 1-(bromomethyl)-2-chloro-3-(trifluoromethyl)benzene 
• 476620-55-0 (2-bromo-4,5-difluorophenyl)methanol 

Relevant academic research and scientific papers

Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of spirocyclic piperidines

The discovery and SAR of a novel series of spirocyclic renin inhibitors are described herein. It was found that by restricting the northern aromatic plate to the bioactive conformation through spirocyclization, increase in renin potency and decrease in hE