136058-68-9

Upstream product

• 518343-57-2 3-(4-methoxy-benzoylamino)-4-oxo-pentanoic acid benzyl ester 
• 518343-80-1 [2-(4-methoxy-phenyl)-5-methyl-oxazol-4-yl]-acetic acid benzyl ester 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 136058-69-0 2-[2-(4-methoxyphenyl)-5-methyl-oxazol-4-yl]-ethanol 

Relevant academic research and scientific papers

Application of the Dakin-West reaction for the synthesis of oxazole-containing dual PPARα/γ agonists

An improved method for the preparation of a series of oxazole-containing dual PPARα/γ agonists is described. A synthetic sequence utilizing a Dakin-West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry or in pivotal SAR intermediates derived from aspartic acid.

Oxazolidinedione hypoglycemic agents

Compounds of the formulae STR1 where R is cycloalkyl or aryl; R1 is alkyl, X is O or C=O; A is O or S; and B is N or CH are useful as hypoglycemic agents.

Oxazolidinedione hypoglycemic agents

Compounds of the formulae where R is cycloalkyl or aryl; R1 is alkyl, X is O or C=O; A is O or S; and B is N or CH are useful as hypoglycemic agents.