136059-92-2Relevant academic research and scientific papers
Method for synthesizing N-Boc-L-propargyl glycine
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Paragraph 0041; 0042; 0048; 0049; 0055; 0056, (2017/09/26)
The invention provides a method for synthesizing N-Boc-L-propargyl glycine. According to the synthetic method, N-glycine ethyl ester serves as an initial raw material, and a target compound is synthesized through a three-step reaction. In the product preparation process, chiral synthesis is performed in the second step by adopting a chiral reagent, and the ee value of the product is increased. In the final step, a 'one-pot' process is adopted, the purification and treatment process of the intermediate link is reduced, the process operation is simplified, the solvent usage amount and the sewage discharge amount are reduced, the production cost is reduced, energy conservation and consumption reduction are realized, and the influence on the environment is alleviated. According to the product prepared by the process, the total yield is more than 70%, the purity detected by HPLC (High Performance Liquid Chromatography) is more than 99%, and the ee value is more than 98%. The method disclosed by the invention is easy to operate, high in yield and high in purity and is favorable for large-scale industrial production.
C2-symmetric pyrrolidine-based chiral ammonium salts as a phase-transfer catalyst
Ishikawa, Tatsuya,Nagata, Kazuhiro,Kani, Sachiko,Matsuo, Mamoru,Sano, Daisuke,Kanemitsu, Takuya,Miyazaki, Michiko,Itoh, Takashi
experimental part, p. 2577 - 2588 (2012/01/06)
Chiral pyrrolidinium salts having substituents at the α, α' positions were synthesized to develop a chiral phase-transfer catalyst which have more simplified structure. The catalytic function of these synthesized catalysts was evaluated using asymmetric b
