1360599-75-2Relevant academic research and scientific papers
Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine
Wu, Zhicai,Yang, Cangming,Xiong, Yusheng,Feng, Zhe,Lombardo, Matthew,Verras, Andreas,Chabin, Renee M.,Xu, Suoyu,Tong, Xinchun,Xie, Dan,Lassman, Mike E.,Bhatt, Urmi R.,Garcia-Calvo, Margarita M.,Geissler, Wayne,Shen, Zhu,Chen, Qing,Sinharoy, Ranabir,Hale, Jeffrey J.,Tata, James R.,Pinto, Shirly,Shen, Dong-Ming,Colletti, Steven L.
, p. 1774 - 1778 (2012)
Efforts to modify the central proline portion of lead compound 4 lead to the discovery of novel prolylcarboxypeptidase (PrCP) inhibitors. Especially, replacement with alanine afforded compound 19 displaying more potent human and mouse PrCP inhibitory activity than 4 and an overall comparable profile.
