1360614-08-9

Upstream product

• 589-18-4 4-Methylbenzyl alcohol 
• 136-95-8 2-amino-benzthiazole 
• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 

Relevant academic research and scientific papers

Combining photo-redox and enzyme catalysis for the synthesis of 4H-pyrimido[2,1-b] benzothiazole derivatives in one pot

A novel strategy combining visible-light and enzyme catalysis in one pot for the synthesis of 4H-pyrimido[2,1-b] benzothiazole derivatives from alcohols is described for the first time. Fourteen 4H-pyrimido[2,1-b] benzothiazole derivatives were prepared with yields of up to 98% under mild reaction conditions by a simple operation. The photoorgano catalyst rose Bengal (rB) was employed to oxyfunctionalise alcohols to aldehydes. Compared with aldehydes, alcohols with more stable properties and lower cost, thus we used photocatalysis to oxidize alcohols into aldehydes. Next, the enzyme was used to further catalyze the reaction of Biginelli to produce the target product of 4H-pyrimidine [2,1-b] benzothiazole. Experimental results show that this method provides a more efficient and eco-friendly strategy for the synthesis of 4H-pyrimido[2,1-b] benzothiazole derivatives.

Colorimetric Metal Sensing of Fe3+ and Cr3+ and Photophysical and Electrochemical Studies Based on Benzo[4,5]thiazolo[3,2- a]pyrimidine-3-carboxylate and Its Derivatives

Benzo[4,5]thiazolo[3, 2-a]pyrimidine-3-carboxylate derivatives (4a-i) containing electron-donor and electron-acceptor groups with remarkable photophysical and electrochemical properties were synthesized. The changes in absorption properties of compound 4a

Agar: A novel, efficient, and biodegradable catalyst for the one-pot three-component and green synthesis of 2,3-dihydroquinazolin-4(1H)-one, 4H-pyrimidobenzothiazole and 2-aminobenzothiazolomethylnaphthol derivatives

3-(2′-Benzothiazolyl)-2,3-dihydroquinazolin-4(1H)- one, 1-((benzo[d]thiazol-2-ylamino) (aryl)-methyl)naphthalen-2-ol and 4H-pyrimido[2,1-b][1,3]benzothiazoles derivatives were prepared via one-pot three-component reaction of arylaldehydes, 2-aminobenzothiazole and isatoic anhydride or β-naphthol or ethyl/methyl acetoacetate in the presence of agar as a highly efficient homogenous catalyst. The use of a non-toxic and biodegradable catalyst, as well as high yields, short reaction time, simple work-up and green conditions are the most important advantages of this method. Graphical Abstract: [Figure not available: see fulltext.]

Synthesis and study of the antimicrobial activity of novel tricyclic 2hpyrimido[ 2,1-b]benzothiazoles

Efficient synthesis of 4H-pyrimido[2,1-b]benzothiazoles by novel one-pot three-component reaction of an aldehyde, β-ketoester and 2-aminobenzothiazole using sulphamic acid as a catalyst is described. All synthesized compounds were evaluated for in vitro a