136067-94-2

Upstream product

• 74-93-1 methylthiol 
• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 2373-51-5 chloro-methylsulfanyl-methane 
• 116332-61-7 N-methoxy-N-methyl-4-trifluoromethylbenzamide 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 5188-07-8 sodium thiomethoxide 
• 95727-89-2 4-(trifluoromethyl)phenyl chloromethylketone 

Downstream Products

• 192862-15-0 2,2-Difluoro-2-(methylthio)-1-[4-(trifluoromethyl)phenyl]-1-ethanone 
• 192862-20-7 2-[difluoro(methylthio)methyl]-2-[4-(trifluoromethyl)phenyl]oxirane 
• 192861-89-5 1,1-difluoro-1-(methylthio)-3-(1H-1,2,4-triazol-1-yl)-2-[4-(trifluoromethyl)phenyl]-2-propanol 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 62151-61-5 (2RS,4SR)-4-(tert-butyl)-2-(methylthio)cyclohexanone 
• 60774-46-1 cis-4-tert-Butyl-2-phenylthiocyclohexanone 

Relevant academic research and scientific papers

Substituted α-Sulfur Methyl Carbanions: Effective Homologating Agents for the Chemoselective Preparation of β-Oxo Thioethers from Weinreb Amides

The proper generation of α-thiomethyllithium reagents via reductive lithiation or deprotonation followed by reaction with variously functionalized Weinreb amides represents an excellent method to access β-oxo thioethers. The procedure is adaptable to alky

Rh/DuanPhos-Catalyzed Asymmetric Hydrogenation of β-Acetylamino Vinylsulfides: An Approach to Chiral β-Acetylamino Sulfides

Rh/DuanPhos-catalyzed asymmetric hydrogenation of challenging β-acetylamino vinylsulfides has been developed, affording chiral β-acetylamino sulfides with high yields and excellent ee's (up to 99% ee). This novel methodology provides an efficient and concise synthetic route to chiral β-acetylamino sulfides. The potential utility of this protocol in the synthesis of Apremilast has also been disclosed.

New antifungal 1,2,4-triazoles with difluoro(substituted sulfonyl)methyl moiety

New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via α,α-difluoro-α-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus

α, α-gem-difluorination of α-(alkylthio)acetophenone derivatives with N-Fluoropyridinium salts

The α, α-gem-difluorination of 2',4'-difluoro- α(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2',4',α-tetrafluoro-α-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields than the reaction without additives were obtained. The gem- difluorination reaction using FP-T300 in the presence of zinc bromide was applicable to other α-(alkylthio)acetophenone derivatives (1).

Triazole derivatives and a composition for treating mycoses

A triazole derivative is disclosed. The compound have a general formula, STR1 wherein R1 and R2 represent a hydrogen atom or a lower alkyl group, or R1 and R2 together form a lower alkylene group, R3