1360800-81-2

Upstream product

• 1347738-33-3 (R)-4-benzyl-3-((S)-3-((benzyloxy)methyl)hex-5-enoyl)-1,3-oxazolidin-2-one 
• 74-88-4 methyl iodide 

Downstream Products

• 1347738-38-8 dimethyl ((4S,5R)-4-((benzyloxy)methyl)-5-methyl-6-oxocyclohex-1-en-1-yl)phosphonate 
• 1347738-37-7 dimethyl ((3R,4S)-4-((benzyloxy)methyl)-3-methyl-2-oxohept-6-en-1-yl)phosphonate 
• 1347738-36-6 (2R,3S)-3-((benzyloxy)methyl)-N-methoxy-N,2-dimethylhex-5-enamide 
• 1347738-41-3 (2R,3S)-3-benzyloxymethyl-2-methylhex-5-enoic acid 
• 1347738-39-9 C₆₀H₇₀O₈Si 
• 1333325-52-2 C₆₀H₇₀O₈Si 
• 1333325-51-1 (3S,4S)-4-tert-butyldimethylsilyloxymethyl-6-tert-butyldiphenylsilyloxy-3-methyl-2-trimethylsilyloxyhex-1-ene 
• 1333325-50-0 (3S,4S)-4-tert-butyldimethylsilyloxymethyl-6-tert-butyldiphenylsilyloxy-3-methylhexan-2-one 
• 1333325-49-7 (3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2,3-dimethyltetrahydrofuran-2-ol 
• 1333325-30-6 (3S,4S)-dimethyl (4-(tert-butyldimethylsilyloxy)methyl-6-tert-butyldiphenylsilyloxy-3-methyl-2-oxohexyl)phosphonate 
• 1333325-48-6 dimethyl ((3S,4S)-4-(2-tert-butyldiphenylsilyloxyethyl)-2-hydroxy-3-methyltetrahydrofuran-2-yl)methylphosphonate 
• 1333325-47-5 (4S)-4-(2-tert-butyldiphenylsilyloxyethyl)dihydrofuran-2(3H)-one 
• 1333325-46-4 (S)-2-(2-tert-butyldiphenylsilyloxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate 
• 1333325-55-5 (S)-2-(2-hydroxyethyl)-4-oxo-4-((R)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)but-1-yl acetate 

Relevant academic research and scientific papers

Formal synthesis of berkelic acid: A lesson in α-alkylation chemistry

The full details of our enantioselective formal synthesis of the biologically active natural product berkelic acid are described. The insertion of the C-18 methyl group proved challenging, with three different approaches investigated to install the correc