1333325-52-2

Upstream product

• 6121-79-5 dimethyl 4-carboxy-3,5-dihydroxyhomophthalate 
• 100-39-0 benzyl bromide 
• 1347738-37-7 dimethyl ((3R,4S)-4-((benzyloxy)methyl)-3-methyl-2-oxohept-6-en-1-yl)phosphonate 
• 1347738-36-6 (2R,3S)-3-((benzyloxy)methyl)-N-methoxy-N,2-dimethylhex-5-enamide 
• 1360801-31-5 (R)-3-((2R,3S)-3-((benzyloxy)methyl)-2-methylhex-5-enoyl)-4-isopropyl-1,3-oxazolidin-2-one 
• 1347738-41-3 (2R,3S)-3-benzyloxymethyl-2-methylhex-5-enoic acid 
• 1360800-81-2 (R)-4-benzyl-3-((2R,3S)-3-((benzyloxy)methyl)-2-methylhex-5-enoyl)-1,3-oxazolidin-2-one 
• 1347738-35-5 (R)-3-((2R,3S)-3-((benzyloxy)methyl)-2-methylhex-5-enoyl)-4-phenyl-1,3-oxazolidin-2-one 
• 1347738-34-4 (R)-3-((S)-3-((benzyloxy)methyl)hex-5-enoyl)-4-isopropyl-1,3-oxazolidin-2-one 
• 1347738-33-3 (R)-4-benzyl-3-((S)-3-((benzyloxy)methyl)hex-5-enoyl)-1,3-oxazolidin-2-one 
• 1347738-32-2 (R)-3-((S)-3-((benzyloxy)methyl)hex-5-enoyl)-4-phenyl-1,3-oxazolidin-2-one 
• 1333325-43-1 (3R)-benzyl 6,8-bis(benzyloxy)-1-oxo-3-pentylisochroman-7-carboxylate 
• 1333325-41-9 1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-oxohept-3-ynyl)isophthalate 
• 1333325-39-5 1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate 

Downstream Products

• 1141365-47-0 2-propenyl (2S,3S,3'aS,4S,5'R)-4-[2-[(1,1-dimethylethyl)diphenylsilyloxy]ethyl]-3',3'a,4,5,5',6'-hexahydro-3-methyl-5'-pentyl-8'-(2-propenyloxy)-spiro[furan-2(3H),2'-[2H]pyrano[2,3,4-de][1]benzopyran]-9'-carboxylate 
• 1182098-75-4 C₃₉H₅₀O₇Si 

Relevant academic research and scientific papers

Formal synthesis of berkelic acid: A lesson in α-alkylation chemistry

The full details of our enantioselective formal synthesis of the biologically active natural product berkelic acid are described. The insertion of the C-18 methyl group proved challenging, with three different approaches investigated to install the correc