136088-21-6

Basic information

• Product Name: 2-Oxazolidinone, 3-[(2S,3S)-3-[(2-aminophenyl)thio]-2-[(2-methoxyethoxy)methoxy]-3-(4- methoxyphenyl)-1-oxopropyl]-4-(1-methylethyl)-, (4S)-
• CAS NO: 136088-21-6
• Molecular Formula: C26H34N2O7S
• Molecular Weight: 518.631
• Mol File: 136088-21-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 3-[(2S,3S)-3-[(2-aminophenyl)thio]-2-[(2-methoxyethoxy)methoxy]-3-(4- methoxyphenyl)-1-oxopropyl]-4-(1-methylethyl)-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 3-[(2S,3S)-3-[(2-aminophenyl)thio]-2-[(2-methoxyethoxy)methoxy]-3-(4- methoxyphenyl)-1-oxopropyl]-4-(1-methylethyl)-, (4S)-(136088-21-6)
• EPA Substance Registry System: 2-Oxazolidinone, 3-[(2S,3S)-3-[(2-aminophenyl)thio]-2-[(2-methoxyethoxy)methoxy]-3-(4- methoxyphenyl)-1-oxopropyl]-4-(1-methylethyl)-, (4S)-(136088-21-6)

Safety Data

• Hazardous Substances Data: 136088-21-6(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 188686-10-4 (S)-3-[3-Hydroxy-2-(2-methoxy-ethoxymethoxy)-3-(4-methoxy-phenyl)-propionyl]-4-isopropyl-oxazolidin-2-one 
• 928007-17-4 (S)-3-(2-methoxyethoxy)methyloxyacetyl-4-(1-methylethyl)-2-oxazolidinone 
• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 
• 136057-77-7 (S)-4-Isopropyl-3-[(Z)-2-(2-methoxy-ethoxymethoxy)-3-(4-methoxy-phenyl)-acryloyl]-oxazolidin-2-one 
• 137-07-5 2-amino-benzenethiol 
• 136057-78-8 (S)-4-Isopropyl-3-[(E)-2-(2-methoxy-ethoxymethoxy)-3-(4-methoxy-phenyl)-acryloyl]-oxazolidin-2-one 

Downstream Products

• 142142-08-3 (2S,3S)-3-(2-Methoxy-ethoxymethoxy)-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 42399-49-5 (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 

Relevant articles and documents

Asymmetric construction of two contiguous stereocenters by diastereoface differentiating addition reaction of thiols to chiral imides: Formal synthesis of (+)-diltiazem

A high degree of diastereoselectivity has been achieved on the asymmetric construction of two contiguous stereocenters by the conjugate addition of thiols to α,β-unsaturated imides possessing Evans's chiral auxiliary. Addition reactions of thiophenol to chiral E- and Z-2-methylcrotonyl imides 4 proceeded with high diastereoface selectivities. Diastereoselectivities were discussed when E- and Z-imides 4 and 5 were used as the substrates. A successful application was demonstrated by the formal synthesis of a clinically useful cardiac drug, (+)-diltiazem.