1360880-15-4Relevant academic research and scientific papers
Total synthesis of danshenspiroketallactone
Chorley, Daniel F.,Chen, Jack Li-Yang,Furkert, Daniel P.,Sperry, Jonathan,Brimble, Margaret A.
, p. 128 - 130 (2012/02/03)
Described herein is the first synthesis of the monobenz-annulated 5,5-spiroketals danshenspiroketallactone and epi-danshen-spiroketallactone, two components of the traditional Chinese medicine Danshen. Key features of the synthesis include a directed metallation-lactonisation sequence to install the isobenzofuranone moiety and an oxidative radical cyclisation to afford the monobenz-annulated 5,5-spiroketal. Georg Thieme Verlag Stuttgart. New York.
