136092-41-6Relevant academic research and scientific papers
Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease
Bilousova, Tina,Campagna, Jesus,Chandra, Sujyoti,Cohn, Whitaker,Elias, Chris J.,Focht, Samantha,Garg, Neil K.,Gylys, Karen H.,Jagodzinska, Barbara,John, Varghese,Knapp, Rachel R.,Melnik, Mikhail,Simmons, Bryan J.,Spilman, Patricia,Vadivel, Kanagasabai,Zhu, Chunni
, p. 1671 - 1684 (2020)
We report the discovery of a novel class of compounds that function as dual inhibitors of the enzymes neutral sphingomyelinase-2 (nSMase2) and acetylcholinesterase (AChE). Inhibition of these enzymes provides a unique strategy to suppress the propagation
COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
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, (2021/07/17)
Provided herein are compounds of Formula I and their salts, and compositions thereof that are useful for modulating neutral sphingomyelinase 2 (n-SMase2) and/or acetylcholinesterase (AChE) in cells. Also disclosed herein are methods of using the disclosed
