ACS Chemical Biology p. 1671 - 1684 (2020)
Update date:2022-08-05
Topics:
Bilousova, Tina
Campagna, Jesus
Chandra, Sujyoti
Cohn, Whitaker
Elias, Chris J.
Focht, Samantha
Garg, Neil K.
Gylys, Karen H.
Jagodzinska, Barbara
John, Varghese
Knapp, Rachel R.
Melnik, Mikhail
Simmons, Bryan J.
Spilman, Patricia
Vadivel, Kanagasabai
Zhu, Chunni
We report the discovery of a novel class of compounds that function as dual inhibitors of the enzymes neutral sphingomyelinase-2 (nSMase2) and acetylcholinesterase (AChE). Inhibition of these enzymes provides a unique strategy to suppress the propagation
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