1361004-95-6

Basic information

• Product Name: 7-chloro-3-methyl-2-(3-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4(1H)-one
• Synonyms: 7-chloro-3-methyl-2-(3-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4(1H)-one
• CAS NO: 1361004-95-6
• Molecular Weight: 443.853
• Mol File: 1361004-95-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-chloro-3-methyl-2-(3-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-3-methyl-2-(3-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4(1H)-one(1361004-95-6)
• EPA Substance Registry System: 7-chloro-3-methyl-2-(3-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4(1H)-one(1361004-95-6)

Safety Data

• Hazardous Substances Data: 1361004-95-6(Hazardous Substances Data)

Upstream product

• 1416277-01-4 (3-chlorophenyl)(mesityl)iodonium trifluoromethanesulfonate 
• 874-86-2 4-cyanobenzyl chloride 
• 1632070-96-2 4-(4-(trifluoromethoxy)benzyl)benzonitrile 
• 625-99-0 3-iodochlorobenzene 
• 87199-16-4 3-Formylphenylboronic acid 
• 50824-05-0 4-trifluoromethoxybenzyl bromide 
• 40928-13-0 4-chloroisatoic anhydride 
• 1361005-60-8 3-(4-(trifluoromethoxy)benzyl)benzaldehyde 
• 1361968-02-6 5-chloro-2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)aniline 
• 1361005-69-7 1-(3-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-one 
• 1375519-59-7 1-(3-(4-(trifluoromethoxy)benzyl)phenyl)propan-1-ol 

Relevant articles and documents

A Modular Synthesis of 4-Aminoquinolines and [1,3] N-to-C Rearrangement to Quinolin-4-ylmethanesulfonamides

A copper-catalyzed regiocontrolled three-component reaction afforded diversified 4-aminoquinolines using nitriles, diaryliodoniums, and ynamides. The C7-substituted regioisomers were formed regioselectively when meta-substituted phenyliodonium salts were used. [1,3] N-to-C rearrangement of the products to quinolin-4-ylmethanesulfonamides and simultaneous deprotection of benzyl and sulfonamide group were newly developed. Finally, antimalarial CK-2-68 was successfully prepared.

ANTIMALARIAL COMPOUNDS

The present invention relates to antimalarial compounds. More specifically, the present invention relates to novel substituted quinolone derivatives of formula (I) and related quinoline derivatives of formula (II) as defined herein that possess potent ant